Chlordecone pretreatment alters [14C]chlordecone and [14C]cholesterol transport kinetics in the perfused rat liver.

@article{Gilroy1994ChlordeconePA,
  title={Chlordecone pretreatment alters [14C]chlordecone and [14C]cholesterol transport kinetics in the perfused rat liver.},
  author={D J Gilroy and H M Carpenter and Lawrence R. Curtis},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1994},
  volume={22 2},
  pages={286-92}
}
Previous work demonstrated that pretreatment of mice with low doses of the organochlorine insecticide chlordecone (CD) altered the tissue disposition of a subsequent [14C]CD or [14C]cholesterol challenge dose. The profile of these changes was consistent with the induction of a protein integral to hepatic CD/cholesterol turnover. The present study was undertaken to confirm similar in vivo effects in the rat and to analyze potential CD-induced changes in hepatic transport kinetics in the perfused… CONTINUE READING

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