Chloramphenicol significantly affects the pharmacokinetics of oral methadone in Greyhound dogs.

@article{KuKanich2015ChloramphenicolSA,
  title={Chloramphenicol significantly affects the pharmacokinetics of oral methadone in Greyhound dogs.},
  author={Butch KuKanich and Kate Stenske Kukanich},
  journal={Veterinary anaesthesia and analgesia},
  year={2015},
  volume={42 6},
  pages={597-607}
}
OBJECTIVE To assess the effects of cytochrome P450 (CYP) inhibitors (ketoconazole, chloramphenicol, trimethoprim, fluoxetine, cimetidine and medetomidine) in various combinations on the pharmacokinetics of oral methadone in Greyhound dogs to determine the specific effects of the different inhibitors and if a clinically relevant interaction occurs. STUDY DESIGN Non-randomized, sequential design. ANIMALS Six healthy Greyhound dogs (three male, three female). METHODS Canine CYP inhibitors… CONTINUE READING

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