Chloramphenicol clearance in typhoid fever: Implications for therapy

@article{Bhutta1992ChloramphenicolCI,
  title={Chloramphenicol clearance in typhoid fever: Implications for therapy},
  author={Zulfiqar Ahmed Bhutta and Sarfaraz K Niazi and A Suria},
  journal={The Indian Journal of Pediatrics},
  year={1992},
  volume={59},
  pages={213-219}
}
We prospectively studied the pharmacokinetics of intravenous Chloramphenicol succinate (CS) in children (age 6 months-14 years) with culture proven typhoid fever (n=30) and non typhoidal illnesses (n=10). CS was administered in three different dosage regimens (50, 75 and 100 mg/kg/d-q 6 hourly). Liver function tests were monitored. Plasma trough and peak chloramphenicol concentrations were measured by HPLC analysis after 42 hrs. The 50 mg/kg/day dosage schedule was terminated midway through the… Expand
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