Chloramphenicol clearance in typhoid fever: Implications for therapy

  title={Chloramphenicol clearance in typhoid fever: Implications for therapy},
  author={Zulfiqar Ahmed Bhutta and Sarfaraz K Niazi and A Suria},
  journal={The Indian Journal of Pediatrics},
We prospectively studied the pharmacokinetics of intravenous Chloramphenicol succinate (CS) in children (age 6 months-14 years) with culture proven typhoid fever (n=30) and non typhoidal illnesses (n=10). CS was administered in three different dosage regimens (50, 75 and 100 mg/kg/d-q 6 hourly). Liver function tests were monitored. Plasma trough and peak chloramphenicol concentrations were measured by HPLC analysis after 42 hrs. The 50 mg/kg/day dosage schedule was terminated midway through the… Expand
2 Citations
Epidemiology, Clinical Presentation, Laboratory Diagnosis, Antimicrobial Resistance, and Antimicrobial Management of Invasive Salmonella Infections
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Ultrasonic assisted preparation of CoMoO4 nanoparticles modified electrochemical sensor for chloramphenicol determination
Abstract The mixed metal oxides have been utilized for enhanced electrochemical detection applications owing to their tremendous physicochemical properties and excellent stabilities. Herein, we haveExpand


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A wide variation in both serum levels and clearance amongst babies receiving the same dose was observed, and postnatal age and gestational age accounted for some of the variability in pharmacokinetic response to chloramphenicol. Expand
Chloramphenicol disposition in infants and children.
It is concluded that the marked individual variation in chloramphenicol pharmacokinetics in infants and children requires monitoring of blood concentrations during therapy. Expand
Chloramphenicol pharmacokinetics in infants and young children.
It is concluded that serum chloramphenicol concentrations should be monitored in infants and children after intravenous infusion of chlorampshenicol succinate because of the wide variability in pharmacokinetics. Expand
Chloramphenicol Pharmacokinetics in Hospitalized Patients
The apparent body clearance of chloramphenicol was investigated in 21 hospitalized adult patients on 27 occasions and found to be significantly lower in patients with total serum bilirubin concentrations of >1.5 mg/100 ml, implying the need for a lower therapeutic range of total chlorampshenicol concentration. Expand
Pharmacokinetics of chloramphenicol and chloramphenicol succinate in infants and children.
Variable hydrolysis and renal elimination of nonhydrolyzed chloramphenicol-S reduces the bioavailability of the antibiotic and appears to contribute substantially to the wide variation in apparent half-life and poor correlation between dose and serum concentration of free chlorampenicol. Expand
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Administration of chloramphenicol orally in the palmitate form produces serum concentrations and areas under the disappearance curve similar to those achieved after iv administration of the same dose, indicating that the oral route is an effective method of achieving therapeutic concentrations of chlorampshenicol in serum. Expand
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Chloramphenicol sodium succinate kinetics in critically ill patients
Renal excretion of SCAP was shown to influence CAP serum levels, but no relationship was found between routine liver function studies and CAP ClTB, and the use of such relationships in using CAP in critically ill patients is cautioned. Expand
Studies on the absorption and distribution of chloramphenicol.
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