Chloramphenicol binding site with analogues of chloramphenicol and puromycin.

  title={Chloramphenicol binding site with analogues of chloramphenicol and puromycin.},
  author={Robert Vince and R G Almquist and Clare L Ritter and Susan M Daluge},
  journal={Antimicrobial agents and chemotherapy},
  volume={8 4},
The effect of a series of puromycin analogues and aminoacyl chloramphenicol derivatives on poly(U,C)-directed polyphenylalanine synthesis in an Escherichia coli cell-free system was examined. A comparison between the structures and activities of the puromycin and chloramphenicol analogues was made to examine the proposal that ribosomal binding sites for both antibiotics overlap. Our results suggest that the dichloroacetamido group in the chloramphenicol molecule does not correspond to the role… CONTINUE READING

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