Chlorambucil pharmacokinetics and DNA binding in chronic lymphocytic leukemia lymphocytes.

@article{Bank1989ChlorambucilPA,
  title={Chlorambucil pharmacokinetics and DNA binding in chronic lymphocytic leukemia lymphocytes.},
  author={B B Bank and D N Kanganis and Leonard F. Liebes and Robert Silber},
  journal={Cancer research},
  year={1989},
  volume={49 3},
  pages={554-9}
}
Chlorambucil (CLB) uptake by chronic lymphocytic leukemia lymphocytes was studied using a radiometric and a newly developed high-performance liquid chromatography assay. CLB labeled with 14C in either the chloroethyl group or phenyl ring was used with identical results. Drug accumulation by the cells was found to peak at 30 s, was independent of temperature… CONTINUE READING