Corpus ID: 92401821

Chlamydial infection and the efficiency of MHC class I self-antigen presentation in a lymphoblastoid cell line

@article{Simmons2016ChlamydialIA,
  title={Chlamydial infection and the efficiency of MHC class I self-antigen presentation in a lymphoblastoid cell line},
  author={Ryan S Simmons and Erik D. Cram and A. Palmer and B. Dolan},
  journal={Journal of Immunology},
  year={2016},
  volume={196}
}
The direct MHC class I antigen presentation pathway presents cytosolic proteins for immune surveillance. While this pathway is an attractive target for therapeutics, we must first understand the efficiency of antigen presentation. Previous studies have shown the presentation efficiency from pathogen-derived antigens ranges from 0.03–25%. The intracellular lifestyle of Chlamydia makes them an attractive model to study class I presentation. It is likely that Chlamydia have developed mechanisms to… Expand