Chlamydial Plasmid-Dependent Pathogenicity.

@article{Zhong2017ChlamydialPP,
  title={Chlamydial Plasmid-Dependent Pathogenicity.},
  author={Guangming Zhong},
  journal={Trends in microbiology},
  year={2017},
  volume={25 2},
  pages={
          141-152
        }
}
Most Chlamydia species carry a 7.5kb plasmid encoding eight open reading frames conventionally called plasmid glycoproteins 1-8 or pGP1-8. Although the plasmid is not critical for chlamydial growth in vitro, its role in chlamydial pathogenesis is clearly demonstrated in the genital tracts of mice infected with Chlamydia muridarum, a model for investigating the human pathogen Chlamydia trachomatis. Plasmid-free C. trachomatis is also attenuated in both the mouse genital tract and nonhuman… CONTINUE READING
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