Chlamydial Entry Involves TARP Binding of Guanine Nucleotide Exchange Factors

@inproceedings{Lane2008ChlamydialEI,
  title={Chlamydial Entry Involves TARP Binding of Guanine Nucleotide Exchange Factors},
  author={Brian J Lane and Charla Mutchler and Souhaila Al Khodor and Scott S. Grieshaber and Rey A Carabeo},
  booktitle={PLoS pathogens},
  year={2008}
}
Chlamydia trachomatis attachment to cells induces the secretion of the elementary body-associated protein TARP (Translocated Actin Recruiting Protein). TARP crosses the plasma membrane where it is immediately phosphorylated at tyrosine residues by unknown host kinases. The Rac GTPase is also activated, resulting in WAVE2 and Arp2/3-dependent recruitment of actin to the sites of chlamydia attachment. We show that TARP participates directly in chlamydial invasion activating the Rac-dependent… CONTINUE READING