Chlamydia trachomatis tarp is phosphorylated by src family tyrosine kinases.

  title={Chlamydia trachomatis tarp is phosphorylated by src family tyrosine kinases.},
  author={Travis J. Jewett and Cheryl A. Dooley and David J. Mead and Ted Hackstadt},
  journal={Biochemical and biophysical research communications},
  volume={371 2},
The translocated actin recruiting phosphoprotein (Tarp) is injected into the cytosol shortly after Chlamydia trachomatis attachment to a target cell and subsequently phosphorylated by an unidentified tyrosine kinase. A role for Tarp phosphorylation in bacterial entry is unknown. In this study, recombinant C. trachomatis Tarp was employed to identify the host cell kinase(s) required for phosphorylation. Each tyrosine rich repeat of L2 Tarp harbors a sequence similar to a Src and Abl kinase… CONTINUE READING

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