Chlamydia trachomatis plasmid-encoded Pgp4 is a transcriptional regulator of virulence-associated genes.

@article{Song2013ChlamydiaTP,
  title={Chlamydia trachomatis plasmid-encoded Pgp4 is a transcriptional regulator of virulence-associated genes.},
  author={Lihua Song and John G. H. Carlson and William Michael Whitmire and Laszlo Kari and Kimmo Virtaneva and Daniel E. Sturdevant and Heather S. Watkins and Bing Zhou and Gail L. Sturdevant and Stephen F Porcella and Grant McClarty and Harlan D. Caldwell},
  journal={Infection and immunity},
  year={2013},
  volume={81 3},
  pages={636-44}
}
Chlamydia trachomatis causes chronic inflammatory diseases of the eye and genital tract and has global medical importance. The chlamydial plasmid plays an important role in the pathophysiology of these diseases, as plasmid-deficient organisms are highly attenuated. The cryptic plasmid carries noncoding RNAs and eight conserved open reading frames (ORFs). To understand plasmid gene function, we generated plasmid shuttle vectors with deletions in each of the eight ORFs. The individual deletion… CONTINUE READING

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