Chlamydia trachomatis Disrupts N-Cadherin-Dependent Cell-Cell Junctions and Sequesters β-Catenin in Human Cervical Epithelial Cells

@article{Prozialeck2002ChlamydiaTD,
  title={Chlamydia trachomatis Disrupts N-Cadherin-Dependent Cell-Cell Junctions and Sequesters $\beta$-Catenin in Human Cervical Epithelial Cells},
  author={W. Prozialeck and M. Fay and P. Lamar and C. Pearson and I. Sigar and K. Ramsey},
  journal={Infection and Immunity},
  year={2002},
  volume={70},
  pages={2605 - 2613}
}
ABSTRACT The cadherin/catenin complex serves as an important structural component of adherens junctions in epithelial cells. Under certain conditions, β-catenin can be released from this complex and interact with transcription factors in the nucleus to stimulate the expression of genes that regulate apoptosis and cell cycle control. While studying the effects of the bacterial pathogen Chlamydia trachomatis on human cervical epithelial cells in culture, we observed that C. trachomatis caused the… Expand

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