Chlamydia trachomatis Alters Iron-Regulatory Protein-1 Binding Capacity and Modulates Cellular Iron Homeostasis in HeLa-229 Cells

@inproceedings{Vardhan2009,
  title={
					Chlamydia trachomatis Alters Iron-Regulatory Protein-1 Binding Capacity and Modulates Cellular Iron Homeostasis in HeLa-229 Cells},
  author={Harsh Vardhan and Apurb Rashmi Bhengraj and Rajneesh Ranjan Jha and Aruna Singh Mittal},
  booktitle={Journal of biomedicine & biotechnology},
  year={2009}
}
  • Harsh Vardhan, Apurb Rashmi Bhengraj, +1 author Aruna Singh Mittal
  • Published in
    Journal of biomedicine…
    2009
  • Biology, Medicine
  • Chlamydia trachomatis (CT) is the leading cause of diseases related to reproductive health and iron plays important role in chlamydial pathogenesis. Iron homeostasis in chlamydia-infected cells is not clear thus far. This study shows that expression of the transferrin receptor (TfR) is downregulated, whereas expression of the ferritin heavy chain is upregulated in CT-infected HeLa-229 cells. Expression of iron-regulatory protein (IRP)-1 predominates over IRP-2 in infected cells. In infected… CONTINUE READING

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