Chlamydia-specific CD4 T cell clones control Chlamydia muridarum replication in epithelial cells by nitric oxide-dependent and -independent mechanisms.

@article{Jayarapu2010ChlamydiaspecificCT,
  title={Chlamydia-specific CD4 T cell clones control Chlamydia muridarum replication in epithelial cells by nitric oxide-dependent and -independent mechanisms.},
  author={Krupakar Jayarapu and Micah S. Kerr and Susan Ofner and Raymond M. Johnson},
  journal={Journal of immunology},
  year={2010},
  volume={185 11},
  pages={6911-20}
}
Chlamydia trachomatis serovars D-K are sexually transmitted intracellular bacterial pathogens that replicate in epithelial cells lining the human reproductive tract. It is clear from knockout mice and T cell depletion studies using Chlamydia muridarum that MHC class II and CD4 T cells are critical for clearing bacteria from the murine genital tract. It is not clear how CD4 T cells interact with infected epithelial cells to mediate bacterial clearance in vivo. Previous work using an epithelial… CONTINUE READING
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