Chlamydia pneumoniae impairs the innate immune response in infected epithelial cells by targeting TRAF3.

Abstract

Type I IFNs are induced during microbial infections and have well-characterized antiviral activities. TRAF3 is a signaling molecule crucial for type I IFN production and, therefore, represents a potential target for disarming immune responses. Chlamydia pneumoniae is a human pathogen that primarily infects respiratory epithelial cells; the onset of symptoms… (More)
DOI: 10.4049/jimmunol.1202443

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