Chlamydia pneumoniae and chlamydial heat shock protein 60 stimulate proliferation of human vascular smooth muscle cells via toll-like receptor 4 and p44/p42 mitogen-activated protein kinase activation.

@article{Sasu2001ChlamydiaPA,
  title={Chlamydia pneumoniae and chlamydial heat shock protein 60 stimulate proliferation of human vascular smooth muscle cells via toll-like receptor 4 and p44/p42 mitogen-activated protein kinase activation.},
  author={Sebastian J Sasu and David LaVerda and Nilofer Qureshi and Douglas T Golenbock and Debbie Beasley},
  journal={Circulation research},
  year={2001},
  volume={89 3},
  pages={
          244-50
        }
}
An early component of atherogenesis is abnormal vascular smooth muscle cell (VSMC) proliferation. The presence of Chlamydia pneumoniae in many atherosclerotic lesions raises the possibility that this organism plays a causal role in atherogenesis. In this study, C pneumoniae elementary bodies (EBs) rapidly activated p44/p42 mitogen-activated protein kinases (MAPKs) and stimulated proliferation of VSMCs in vitro. Exposure of VSMCs derived from human saphenous vein to C pneumoniae EBs (3x10(7… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 98 extracted citations

TLR4-Activated MAPK-IL-6 Axis Regulates Vascular Smooth Muscle Cell Function

International journal of molecular sciences • 2016
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 46 references

Similar Papers

Loading similar papers…