Chlamydia pneumoniae and atherosclerosis

@article{Belland2004ChlamydiaPA,
  title={Chlamydia pneumoniae and atherosclerosis},
  author={Robert J. Belland and Scot P. Ouellette and Jens Gieffers and Gerald I. Byrne},
  journal={Cellular Microbiology},
  year={2004},
  volume={6}
}
Exposure to Chlamydia pneumoniae is extremely common, and respiratory infections occur repeatedly among most people. Strong associations exist between C. pneumoniae infection and atherosclerosis as demonstrated by: (i) sero‐epidemiological studies showing that patients with cardiovascular disease have higher titres of anti‐C. pneumoniae antibodies compared with control patients; (ii) detection of the organism within atherosclerotic lesions, but not in adjacent normal tissue by… 

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The strength of the data for individual or groups of pathogens with regard to atherosclerosis pathogenesis and their potential contribution by direct or indirect mechanisms are evaluated and whether the established associations are supportive of the infectious disease paradigm is discussed.

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TLDR
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  • S. Didion
  • Medicine, Biology
    Circulation research
  • 2008
TLDR
The first evidence linking C pneumoniae infection and atherosclerosis was obtained from the finding that individuals with coronary heart disease and acute myocardial infarction were found to posses significantly higher titers of C pneumoniaE –specific IgG antibodies than that in individuals without cardiovascular disease.

Chlamydia pneumoniae infection in patients with carotid artery disease

TLDR
High titers of specific IgG and IgA, which can indicate reinfection or exacerbation of chronic infection, occur statistically more frequent in CAD patients compared to healthy controls and there is an urgent need of standardization of PCR methods detecting DNA Chlamydia pneumoniae in atherosclerotic plaques.

Impact of viral and bacterial infections in coronary artery disease patients

TLDR
The association of ath-erosclerosis with different infectious agents, specifically Chlamydia pneumoniae, Helicobacter pylori, Herpes viruses and periodontal pathogens are described and cited in this review.
...

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