Chlamydia pneumoniae DNA in Peripheral Blood Mononuclear Cells in Healthy Control Subjects and Patients with Diabetes mellitus, Acute Coronary Syndrome, Stroke, and Arterial Hypertension

  title={Chlamydia pneumoniae DNA in Peripheral Blood Mononuclear Cells in Healthy Control Subjects and Patients with Diabetes mellitus, Acute Coronary Syndrome, Stroke, and Arterial Hypertension},
  author={Jakob M{\"u}ller and Dorthe Svenstrup M{\o}ller and Mogens Kj{\ae}r and Ole Nyvad and Niels A. Larsen and Erling Bjerregaard Pedersen},
  journal={Scandinavian Journal of Infectious Diseases},
  pages={704 - 712}
Infection with Chlamydia pneumoniae has been suggested to play a role in the development and maintenance of atherosclerosis based on differences in the prevalence of antibodies against Chlamydia pneumoniae in patients with and without atherosclerotic lesions. We evaluated the prevalence of Chlamydia pneumoniae DNA in the white cells of the peripheral blood in 194 patients with diabetes mellitus, 50 patients with acute coronary syndrome, 102 hypertensive patients, 193 patients having suffered a… 
Repetitive Measurements of Chlamydia Pneumoniae DNA in Peripheral Blood Mononuclear Cells in Healthy Control Subjects and Dialysis Patients: A Prospective Study
The prevalence of C. pneumoniae DNA in the white cells of the peripheral blood in 98 dialysis patients and in 52 healthy subjects and a significant association between it and the presence of atherosclerosis in the legs of Dialysis patients may support the hypothesis of an association between infection with C. tuberculosis pneumoniae and the existence or development of Atherosclerosis.
Circulating Chlamydia pneumoniae DNA and advanced coronary artery disease.
Detection of circulating Chlamydophila pneumoniae in patients with coronary artery disease and healthy control subjects.
Serologic findings indicating past exposure to C. pneumoniae do not appear useful as a noninvasive way of detecting the presence of the virus in peripheral blood mononuclear cells, and uniformly negative results with use of highly sensitive methods are in contrast to much of the published literature.
Chlamydia pneumoniae infection in adolescents with type 1 diabetes mellitus.
Chlamydia pneumoniae, an intracellular bacterium, is associated with respiratory diseases, reinfectivity and chronic diseases such as cardiovascular disease, hypertension and stroke. The risk of
Chlamydia pneumoniae seropositivity in adults with acute ischemic stroke: A case–control study
An increased risk of AIS was demonstrated in patients seropositive for C. pneumoniae for IgA antibodies in patients with AIS, and there was no difference in IgA or IgG positivity in different stroke subtypes.
Development of diabetes in non‐obese diabetic mice promotes Chlamydia pneumoniae dissemination from lung to peripheral blood
The development of diabetes in NOD mouse appears to be one of critical factors for promoting the dissemination of C. pneumoniae from lung to peripheral blood.
Chronic Chlamydia pneumoniae Infection and Stroke in Cameroon: A Case-Control Study
A strong statistical association between (IgA, and not IgG, as a serological marker of) chronic C pneumoniae infection and stroke for the first time in a resident indigenous African population is shown.
Burden of infection and insulin resistance in healthy middle-aged men.
Pathogen burden showed the strongest association with insulin resistance, especially with enteroviruses and C. pneumoniae seropositivity, and the associations were stronger when considering the infection burden.
Common infections and the risk of stroke
Increasing evidence indicates that the aggregate burden of chronic and/or past infections rather than any one single infectious disease is associated with the risk of stroke.


Chlamydia pneumoniae DNA in peripheral blood mononuclear cells in dialysis patients, renal transplant recipients and healthy controls
The results are consistent with the hypothesis that Chlamydia pneumoniae is associated with the pathogenesis of atherosclerosis and dialysis patients have a higher prevalence of Chlam Lydia pneumoniae DNA than healthy controls.
Association of circulating Chlamydia pneumoniae DNA with cardiovascular disease: a systematic review
C. pneumoniae DNA detection was associated with CV disease in unadjusted case-control studies, however, adjustment for potentially confounding measures such as smoking or season, and standardization of laboratory methods are needed to confirm this association.
Chlamydia pneumoniae antibodies in severe essential hypertension.
Data support an association of C. pneumoniae with severe essential hypertension in a multiracial British population and provide no evidence of a predisposition to develop left ventricular hypertrophy in hypertensive patients with C. infections.
Association Between Infection With Helicobacter pylori and Chlamydia pneumoniae and Risk of Ischemic Stroke Subtypes: Results From a Population-Based Case-Control Study
This population-based study does not provide evidence of any strong association between the immune response to C pneumoniae as a marker of prior infection and ischemic stroke, and further studies are required to reveal the role of chronic H pylori infection as an independent risk factor for the subgroup small-artery occlusion.
Circulating Chlamydia pneumoniae DNA as a predictor of coronary artery disease.
Chronic Chlamydia pneumoniae infection as a risk factor for coronary heart disease in the Helsinki Heart Study.
The results suggest that chronic C. pneumoniae infection may be a significant risk factor for the development of coronary heart disease.
Confirmed previous infection with Chlamydia pneumoniae (TWAR) and its presence in early coronary atherosclerosis.
Serological evidence for C pneumoniae infection frequently precedes both the earliest and more advanced lesions of coronary atherosclerosis that harbor this intracellular pathogen, suggesting a chronic infection and developmental role in coronary heart disease.
Coronary artery disease and infection with chlamydia pneumonia.
Seropositivity for IgG antibodies to chlamydia pneumonia is considered as a risk factor for coronary artery disease by its association with the atherogenic lipid profile and procoagulant activity.
[Chlamydia pneumoniae in coronary plaques: Increased detection with acute coronary syndrome].
The present in situ findings indicate a pathogenic role of Chlamydiae pneumoniae in human (coronary) plaque rupture, and there was a highly significant prevalence of lesions associated with acute coronary syndrome.
Chlamydia pneumoniae antibody titers are significantly associated with acute stroke and transient cerebral ischemia: the West Birmingham Stroke Project.
The association of cerebral vascular disease with previous C pneumoniae infection and the association of stroke and transient cerebral ischemia with recrudescence of infection are supported.