Chk2 Regulates Cell Cycle Progression during Mouse Oocyte Maturation and Early Embryo Development

@inproceedings{Dai2014Chk2RC,
  title={Chk2 Regulates Cell Cycle Progression during Mouse Oocyte Maturation and Early Embryo Development},
  author={Xiao-Xin Dai and Xing Duan and Honglin Liu and Xiang-Shun Cui and Nam-Hyung Kim and Shao-Chen Sun},
  booktitle={Molecules and cells},
  year={2014}
}
As a tumor suppressor homologue during mitosis, Chk2 is involved in replication checkpoints, DNA repair, and cell cycle arrest, although its functions during mouse oocyte meiosis and early embryo development remain uncertain. We investigated the functions of Chk2 during mouse oocyte maturation and early embryo development. Chk2 exhibited a dynamic… CONTINUE READING