Chk1 knockdown confers radiosensitization in prostate cancer stem cells.

Abstract

Radioresistance is responsible for treatment failure after radiotherapy in localized prostate cancer, while prostate cancer stem cells promote radioresistance by preferential activation of the DNA damage response. Chk1 inhibition has been shown to sensitize many tumor cells to radiation. However, whether Chk1 inhibition… (More)
DOI: 10.3892/or.2012.2068

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