Chk1- and claspin-dependent but ATR/ATM- and Rad17-independent DNA replication checkpoint response in HeLa cells.

@article{RodrguezBravo2006Chk1AC,
  title={Chk1- and claspin-dependent but ATR/ATM- and Rad17-independent DNA replication checkpoint response in HeLa cells.},
  author={Ver{\'o}nica Rodr{\'i}guez-Bravo and Sandra Guaita-Esteruelas and Roger Florensa and Oriol Bachs and Neus Agell},
  journal={Cancer research},
  year={2006},
  volume={66 17},
  pages={
          8672-9
        }
}
When DNA synthesis is inhibited, DNA replication checkpoint is activated to prevent mitosis entry without fully replicated DNA. In Xenopus, caffeine-sensitive kinases [ataxia telangiectasia mutated (ATM) and ATM-related protein (ATR)] are essential in this checkpoint response, but in mammal cells an ATR/ATM-independent checkpoint response to DNA synthesis inhibition exists. Using HeLa cells, which have a caffeine-insensitive checkpoint response, we have analyzed here which molecules known to be… CONTINUE READING

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