Chk1-Mad2 interaction: a crosslink between the DNA damage checkpoint and the mitotic spindle checkpoint.

@article{Chil2013Chk1Mad2IA,
  title={Chk1-Mad2 interaction: a crosslink between the DNA damage checkpoint and the mitotic spindle checkpoint.},
  author={Rosaria Chil{\`a} and Cinzia Celenza and Monica Lupi and Giovanna Damia and Laura Carrassa},
  journal={Cell cycle},
  year={2013},
  volume={12 7},
  pages={1083-90}
}
Chk1 is implicated in several checkpoints of the cell cycle acting as a key player in the signal transduction pathway activated in response to DNA damage and crucial for the maintenance of genomic stability. Chk1 also plays a role in the mitotic spindle checkpoint, which ensures the fidelity of mitotic segregation during mitosis, preventing chromosomal instability and aneuploidy. Mad2 is one of the main mitotic checkpoint components and also exerts a role in the cellular response to DNA damage… CONTINUE READING