Chitosan-solid lipid nanoparticles as carriers for topical delivery of tretinoin.

  title={Chitosan-solid lipid nanoparticles as carriers for topical delivery of tretinoin.},
  author={Daniela M Ridolfi and Priscyla Daniely Marcato and Giselle Zenker Justo and L{\'i}via Cordi and Daisy Maria Machado and Nelson Dur{\'a}n},
  journal={Colloids and surfaces. B, Biointerfaces},
Tretinoin (TRE) or all-trans retinoic acid is employed in the topical treatment of various skin diseases including acne and psoriasis. However, its use is strongly limited by side effects and high chemical instability. TRE encapsulation in nanostructured systems reduces these problems. Chitosan is a biopolymer that exhibits a number of interesting properties such as bioadhesion and antibacterial activity. The aim of this work was to prepare and characterize solid lipid nanoparticles (SLN… CONTINUE READING
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