Chitosan oligosaccharides reduce acetaminophen-induced hepatotoxicity by suppressing CYP-mediated bioactivation

@inproceedings{Yao2015ChitosanOR,
  title={Chitosan oligosaccharides reduce acetaminophen-induced hepatotoxicity by suppressing CYP-mediated bioactivation},
  author={Hsien-Tsung Yao and Mei-Ning Luo and Chenxi Li},
  year={2015}
}
Abstract Chitosan oligosaccharides (COS) are functional foods with various biological activities. Acetaminophen (APAP) is a widely used antipyretic and analgesic drug that can cause acute liver injury when taken in overdose. To investigate the effects of COS on the metabolism and toxicity of acetaminophen in rat liver, rats were fed a controlled diet without or with 1% and 3% COS for 5 weeks and were then intraperitoneally injected with acetaminophen. The activity of cytochrome P450 (CYP… CONTINUE READING