Chitosan oligomers as potential and safe absorption enhancers for improving the pulmonary absorption of interferon-alpha in rats.

@article{Yamada2005ChitosanOA,
  title={Chitosan oligomers as potential and safe absorption enhancers for improving the pulmonary absorption of interferon-alpha in rats.},
  author={Keigo Yamada and Masaaki Odomi and Naoki Okada and Takuya Fujita and Akira Yamamoto},
  journal={Journal of pharmaceutical sciences},
  year={2005},
  volume={94 11},
  pages={
          2432-40
        }
}
Effects of chitosan oligomers on pulmonary absorption of interferon-alpha (IFN) were examined by means of an in vivo pulmonary absorption experiment. Chitosan oligomers used in this study were chitosan dimer, tetramer, hexamer, and water-soluble (WS) chitosan. A significant increase in serum IFN concentrations was observed after intratracheal administration of IFN with these oligomers. Of these chitosan oligomers, 0.5% w/v chitosan hexamer appeared to be more effective in enhancing the… CONTINUE READING
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