Chitosan nanoparticle-loaded mannitol microspheres: structure and surface characterization.

@article{Grenha2007ChitosanNM,
  title={Chitosan nanoparticle-loaded mannitol microspheres: structure and surface characterization.},
  author={Ana Grenha and Bego{\~n}a Seijo and C. Serra and Carmen Remu{\~n}{\'a}n-L{\'o}pez},
  journal={Biomacromolecules},
  year={2007},
  volume={8 7},
  pages={2072-9}
}
In this work, we aimed to characterize the surface and the internal structure of mannitol microspheres containing chitosan/tripolyphosphate nanoparticles, which were prepared by spray-drying. These microspheres were recently proposed as valuable candidates to transport therapeutic protein-loaded nanoparticles to the lungs owing to their favorable aerodynamic properties. To observe the distribution of chitosan nanoparticles and mannitol in the microspheres, specific characterization techniques… CONTINUE READING