Chitosan microparticle preparation for controlled drug release by response surface methodology.

@article{Ko2003ChitosanMP,
  title={Chitosan microparticle preparation for controlled drug release by response surface methodology.},
  author={Jung An Ko and Hee Jun Park and You Soo Park and Sung Joo Hwang and Jun Bom Park},
  journal={Journal of microencapsulation},
  year={2003},
  volume={20 6},
  pages={791-7}
}
The objectives were to investigate the effects of formulation variables on the release of drug and to optimize the formulation of chitosan microparticles loaded with drug for controlled release using response surface methodology. Chitosan microparticles were prepared by dropping a chitosan solution into sodium tripolyphosphate (TPP) through ionic cross-linking. The release behaviour of felodipine as a model drug was affected by preparation variables. A central composite design was used to… CONTINUE READING