Chitosan-mediated in situ biomolecule assembly in completely packaged microfluidic devices.

@article{Park2006ChitosanmediatedIS,
  title={Chitosan-mediated in situ biomolecule assembly in completely packaged microfluidic devices.},
  author={Jung Jin Park and Xiaolong Luo and Hyunmin Yi and Theresa Michelle Valentine and Gregory F. Payne and William E. Bentley and Reza Ghodssi and Gary W. Rubloff},
  journal={Lab on a chip},
  year={2006},
  volume={6 10},
  pages={
          1315-21
        }
}
We report facile in situ biomolecule assembly at readily addressable sites in microfluidic channels after complete fabrication and packaging of the microfluidic device. Aminopolysaccharide chitosan's pH responsive and chemically reactive properties allow electric signal-guided biomolecule assembly onto conductive inorganic surfaces from the aqueous environment, preserving the activity of the biomolecules. A transparent and nonpermanently packaged device allows consistently leak-free sealing… CONTINUE READING

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