Chitosan-graft-polyethylenimine as a gene carrier.

@article{Jiang2007ChitosangraftpolyethylenimineAA,
  title={Chitosan-graft-polyethylenimine as a gene carrier.},
  author={H Jiang and You-Kyoung Kim and Rohidas Balshiram Arote and Jae-Woon Nah and M Cho and Yun-Jaie Choi and Toshihiro Akaike and Chong-su Cho},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2007},
  volume={117 2},
  pages={
          273-80
        }
}
Chitosans have been proposed as biocompatible alternative cationic polymers that are suitable for non-viral delivery. However, the transfection efficiency of chitosan-DNA nanoparticles is still very low. To improve transfection efficiency, we prepared chitosan-graft-polyethylenimine (CHI-g-PEI) copolymer by an imine reaction between periodate-oxidized chitosan and polyethylenimine (PEI). The molecular weight and composition of the CHI-g-PEI copolymer were characterized, using multi-angle laser… CONTINUE READING
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