Chitosan films and hydrogels of chlorhexidine gluconate for oral mucosal delivery.

@article{enel2000ChitosanFA,
  title={Chitosan films and hydrogels of chlorhexidine gluconate for oral mucosal delivery.},
  author={Sevda Şenel and G Ikinci and Sjors M. Kas and A Yousefi-Rad and Mustafa Fevzi Sargon and A. Atill{\^a} Hincal},
  journal={International journal of pharmaceutics},
  year={2000},
  volume={193 2},
  pages={197-203}
}
Topical delivery of antimicrobial agents is the most widely accepted approach aimed at prolonging active drug concentrations in the oral cavity. As most antifungals do not posses inherent ability to bind to the oral mucosa, this is best achieved through improved formulations. Chitosan, a partially deacetylated chitin, which is a biologically safe biopolymer, prolongs the adhesion time of oral gels and drug release from them. Chitosan also inhibits the adhesion of Candida albicans to human… CONTINUE READING