Chitosan coating of copper nanoparticles reduces in vitro toxicity and increases inflammation in the lung.

@article{Worthington2013ChitosanCO,
  title={Chitosan coating of copper nanoparticles reduces in vitro toxicity and increases inflammation in the lung.},
  author={Kristan Sorenson Worthington and Andrea Adamcakova-Dodd and Amaraporn Wongrakpanich and Imali Ama Mudunkotuwa and Kranti Ashok Mapuskar and Vijaya Bharti Joshi and C Allan Guymon and Douglas R. Spitz and Vicki H Grassian and Peter S Thorne and Aliasger K Salem},
  journal={Nanotechnology},
  year={2013},
  volume={24 39},
  pages={395101}
}
Despite their potential for a variety of applications, copper nanoparticles induce very strong inflammatory responses and cellular toxicity following aerosolized delivery. Coating metallic nanoparticles with polysaccharides, such as biocompatible and antimicrobial chitosan, has the potential to reduce this toxicity. In this study, copper nanoparticles were coated with chitosan using a newly developed and facile method. The presence of coating was confirmed using x-ray photoelectron spectroscopy… CONTINUE READING

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