Chitosan-coated solid lipid nanoparticles for insulin delivery.

@article{Fonte2012ChitosancoatedSL,
  title={Chitosan-coated solid lipid nanoparticles for insulin delivery.},
  author={Pedro Fonte and Federico Andrade and Francisca Ara{\'u}jo and Cl{\'a}udia Regina de Andrade and Jos{\'e} Manoel Souza das Neves and Bruno Sarmento},
  journal={Methods in enzymology},
  year={2012},
  volume={508},
  pages={
          295-314
        }
}
The delivery of therapeutic proteins like insulin, exploiting routes of administration different from the traditional injectable forms, has been investigated extensively, taking advantage of the nanotechnology tools available nowadays in the massive drug delivery system pipeline. In this chapter, we describe in detail the preparation of solid lipid nanoparticles (SLN), further coated with the mucoadhesive polymer chitosan, intended for intestinal absorption of insulin after oral administration… CONTINUE READING

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