Chitosan based oligoamine polymers: synthesis, characterization, and gene delivery.

@article{Lu2009ChitosanBO,
  title={Chitosan based oligoamine polymers: synthesis, characterization, and gene delivery.},
  author={Bo Lu and C Wang and De-Qun Wu and Cao Li and Xianzheng Zhang and R Jin-Cong Zhuo},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2009},
  volume={137 1},
  pages={54-62}
}
A series of chitosan-based oligoamine polymers was synthesized from N-maleated chitosan (NMC) via Michael addition with diethylenetriamine (DETA), triethylenetetramine (TETA), tetraethylenepentamine (TEPA) and linear polyethylenimine (M(n) 423), respectively. The resulted polymers exhibited well binding ability to condense plasmid DNA to form complexes with size ranging from 200 to 600 nm when the polymer/DNA weight ratio was above 7. The polymer/DNA complexes observed by scanning electron… CONTINUE READING

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