Chitosan-based nanoparticles for rosmarinic acid ocular delivery--In vitro tests.

@article{Silva2016ChitosanbasedNF,
  title={Chitosan-based nanoparticles for rosmarinic acid ocular delivery--In vitro tests.},
  author={Sara Baptista da Silva and Domingos C Ferreira and Manuela E. Pintado and Bruno Sarmento},
  journal={International journal of biological macromolecules},
  year={2016},
  volume={84},
  pages={
          112-20
        }
}
In this study, chitosan nanoparticles were used to encapsulate antioxidant rosmarinic acid, Salvia officinalis (sage) and Satureja montana (savory) extracts as rosmarinic acid natural vehicles. The nanoparticles were prepared by ionic gelation using chitosan and sodium tripolyphosphate (TPP) in a mass ratio of 7:1, at pH 5.8. Particle size distribution analysis and transmission electron microscopy (TEM) confirmed the size ranging from 200 to 300 nm, while surface charge of nanoparticles ranged… CONTINUE READING
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