Chitosan-based mucoadhesive tablets for oral delivery of ibuprofen.

  title={Chitosan-based mucoadhesive tablets for oral delivery of ibuprofen.},
  author={Ioannis A Sogias and Adrian C. Williams and Vitaliy V Khutoryanskiy},
  journal={International journal of pharmaceutics},
  volume={436 1-2},
Chitosan and its half-acetylated derivative have been compared as excipients in mucoadhesive tablets containing ibuprofen. Initially the powder formulations containing the polymers and the drug were prepared by either co-spray drying or physical co-grinding. Polymer-drug interactions and the degree of drug crystallinity in these formulations were assessed by infrared spectroscopy and differential scanning calorimetry. Tablets were prepared and their swelling and dissolution properties were… CONTINUE READING
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