Chitosan and Chitosan/Ethylene Oxide-Propylene Oxide Block Copolymer Nanoparticles as Novel Carriers for Proteins and Vaccines

@article{Calvo1997ChitosanAC,
  title={Chitosan and Chitosan/Ethylene Oxide-Propylene Oxide Block Copolymer Nanoparticles as Novel Carriers for Proteins and Vaccines},
  author={Patricia R. Calvo and Carmen Remu{\~n}{\'a}n-L{\'o}pez and J. L. Vila-jato and Maria Jose Castro Alonso},
  journal={Pharmaceutical Research},
  year={1997},
  volume={14},
  pages={1431-1436}
}
Purpose. The aim of this study was to investigate the interaction between the components of novel chitosan (CS) and CS/ethylene oxide-propylene oxide block copolymer (PEO-PPO) nanoparticles and to evaluate their potential for the association and controlled release of proteins and vaccines. Methods. The presence of PEO-PPO on the surface of the nanoparticles and its interaction with the CS was identified by X-ray photoelectron spectroscopy (XPS). The mechanism of protein association was… CONTINUE READING
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