Chitosan-Graphene Oxide 3D scaffolds as Promising Tools for Bone Regeneration in Critical-Size Mouse Calvarial Defects

  title={Chitosan-Graphene Oxide 3D scaffolds as Promising Tools for Bone Regeneration in Critical-Size Mouse Calvarial Defects},
  author={Anca Hermenean and Ada Codreanu and Hildegard Herman and Cornel Baltă and Marcel C. Rosu and Ciprian Valentin Mihali and Alexandra Ivan and Sorina Dinescu and Mariana Ionita and Marieta Costache},
  booktitle={Scientific Reports},
Limited self-regenerating capacity of human skeleton makes the reconstruction of critical size bone defect a significant challenge for clinical practice. Aimed for regenerating bone tissues, this study was designed to investigate osteogenic differentiation, along with bone repair capacity of 3D chitosan (CHT) scaffolds enriched with graphene oxide (GO) in critical-sized mouse calvarial defect. Histopathological/histomorphometry and scanning electron microscopy(SEM) analysis of the implants… CONTINUE READING
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