Chitooligosaccharides protect rat cortical neurons against copper induced damage by attenuating intracellular level of reactive oxygen species.

@article{Xu2010ChitooligosaccharidesPR,
  title={Chitooligosaccharides protect rat cortical neurons against copper induced damage by attenuating intracellular level of reactive oxygen species.},
  author={Wei Xu and Han-Chang Huang and Chang-jun Lin and Zhao-feng Jiang},
  journal={Bioorganic & medicinal chemistry letters},
  year={2010},
  volume={20 10},
  pages={3084-8}
}
A large number of evidence has suggests that dyshomeostasis of the redox-active biometals such as copper and other metal ions can lead to oxidative stress in neurons, which plays a key role in the pathology of neurodegenerative disorders. Chitooligosaccharides (COSs) are biodegradation product of chitosan and demonstrated diverse biological activities, Here we first report that protective effects of COSs (M.W. 1500, DD. 90%) against Cu(II) induced neurotoxicity in primary cultured rat cortical… CONTINUE READING

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