Chitinase enzyme activity in CSF is a powerful biomarker of Alzheimer disease.

@article{WatabeRudolph2012ChitinaseEA,
  title={Chitinase enzyme activity in CSF is a powerful biomarker of Alzheimer disease.},
  author={M Watabe-Rudolph and Zhen-ya Song and Ludwig Lausser and Cathrin Schnack and Yvonne Begus-Nahrmann and M Scheithauer and Gerhard Rettinger and Markus Otto and Hayrettin Tumani and Dietmar Rudolf Thal and Johannes Attems and Kurt A. Jellinger and Hans A. Kestler and Christine A. F. von Arnim and Karl Lenhard Rudolph},
  journal={Neurology},
  year={2012},
  volume={78 8},
  pages={569-77}
}
OBJECTIVE DNA damage accumulation in brain is associated with the development of Alzheimer disease (AD), but newly identified protein markers of DNA damage have not been evaluated in the diagnosis of AD and other forms of dementia. METHODS Here, we analyzed the level of novel biomarkers of DNA damage and telomere dysfunction (chitinase activity, N-acetyl-glucosaminidase activity, stathmin, and EF-1α) in CSF of 94 patients with AD, 41 patients with non-AD dementia, and 40 control patients… CONTINUE READING