Chitinase 3-like proteins as diagnostic and prognostic biomarkers of multiple sclerosis.

  title={Chitinase 3-like proteins as diagnostic and prognostic biomarkers of multiple sclerosis.},
  author={Geoffrey Hinsinger and N Gal{\'e}otti and Nicolas Nabholz and S. Urbach and Val{\'e}rie Rigau and Christophe Demattei and Sylvain Lehmann and William Camu and Pierre Labauge and Giovanni Castelnovo and David Brassat and Delphine Loussouarn and Magalie Salou and David-Axel Laplaud and Olivier Casez and J{\"o}el Bockaert and Philippe Marin and Eric Thouvenot},
  journal={Multiple sclerosis},
  volume={21 10},
BACKGROUND Despite sensitivity of MRI to diagnose multiple sclerosis (MS), prognostic biomarkers are still needed for optimized treatment. OBJECTIVE The objective of this paper is to identify cerebrospinal fluid (CSF) diagnostic biomarkers of MS using quantitative proteomics and to analyze their expression at different disease stages. METHODS We conducted differential analysis of the CSF proteome from control and relapsing-remitting MS (RRMS) patients followed by verification by ELISA of… CONTINUE READING
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Multiple sclerosis: Identification and clinical evaluation of at UCSF LIBRARY

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