Chitinase 3-like 1 Regulates Cellular and Tissue Responses via IL-13 Receptor α2

@inproceedings{He2013Chitinase31,
  title={Chitinase 3-like 1 Regulates Cellular and Tissue Responses via IL-13 Receptor α2},
  author={Chuan Hua He and Chun Geun Lee and Charles S Dela Cruz and Chang-Min Lee and Yang Zhou and Farida Ahangari and Bing Ma and Erica L. Herzog and Stephen A. Rosenberg and Yue Li and Adel M. Nour and Chirag R Parikh and Insa M. Schmidt and Yorgo Modis and Lloyd G. Cantley and Jack A Elias},
  booktitle={Cell reports},
  year={2013}
}
Members of the 18 glycosyl hydrolase (GH 18) gene family have been conserved over species and time and are dysregulated in inflammatory, infectious, remodeling, and neoplastic disorders. This is particularly striking for the prototypic chitinase-like protein chitinase 3-like 1 (Chi3l1), which plays a critical role in antipathogen responses where it augments bacterial killing while stimulating disease tolerance by controlling cell death, inflammation, and remodeling. However, receptors that… CONTINUE READING
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