Chitin is a size-dependent regulator of macrophage TNF and IL-10 production.

  title={Chitin is a size-dependent regulator of macrophage TNF and IL-10 production.},
  author={Carla Graziele Azevedo da Silva and C{\'e}cile Chalouni and Adam Williams and Dominik Hartl and Chun Geun Lee and Jack A Elias},
  journal={Journal of immunology},
  volume={182 6},
Chitin is a ubiquitous polysaccharide in fungi, insects, and parasites. We hypothesized that chitin is a size-dependent regulator of innate immunity. To test this hypothesis, we characterized the effects of chitins of different sizes on murine bronchoalveolar or peritoneal macrophages. In these studies, large chitin fragments were inert, while both intermediate-sized chitin (40-70 microm) and small chitin (SC; <40 microm, largely 2-10 microm) stimulated TNF elaboration. In contrast, only SC… CONTINUE READING

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