Chitin and Its Effects on Inflammatory and Immune Responses

@article{Komi2017ChitinAI,
  title={Chitin and Its Effects on Inflammatory and Immune Responses},
  author={D. Elieh Ali Komi and L. Sharma and C. D. Dela Cruz},
  journal={Clinical Reviews in Allergy & Immunology},
  year={2017},
  volume={54},
  pages={213-223}
}
Chitin, a potential allergy-promoting pathogen-associated molecular pattern (PAMP), is a linear polymer composed of N-acetylglucosamine residues which are linked by β-(1,4)-glycosidic bonds. Mammalians are potential hosts for chitin-containing protozoa, fungi, arthropods, and nematodes; however, mammalians themselves do not synthetize chitin and thus it is considered as a potential target for recognition by mammalian immune system. Chitin is sensed primarily in the lungs or gut where it… Expand
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Human Chitinases: Structure, Function, and Inhibitor Discovery.
  • A. Kumar, K. Zhang
  • Biology, Medicine
  • Advances in experimental medicine and biology
  • 2019
  • 5
Phagocytosis-mediated M1 activation by chitin but not by chitosan.
  • 8
Immune Responses of Mammals and Plants to Chitin-Containing Pathogens.
  • 4
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 84 REFERENCES
Chitin regulation of immune responses: an old molecule with new roles.
  • 268
  • Highly Influential
Chitin induces accumulation in tissue of innate immune cells associated with allergy
  • 672
Chitin, Chitinases and Chitinase-like Proteins in Allergic Inflammation and Tissue Remodeling
  • C. Lee
  • Biology, Medicine
  • Yonsei medical journal
  • 2009
  • 127
  • PDF
Chitin particles are multifaceted immune adjuvants.
  • 74
Chitin Modulates Innate Immune Responses of Keratinocytes
  • 92
  • Highly Influential
  • PDF
Chitin Is a Size-Dependent Regulator of Macrophage TNF and IL-10 Production1
  • 207
  • Highly Influential
  • PDF
TLR-2 and IL-17A in Chitin-Induced Macrophage Activation and Acute Inflammation1
  • 204
  • Highly Influential
  • PDF
Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury.
  • 565
Role of mammalian chitinases in inflammatory conditions.
  • 127
  • PDF
...
1
2
3
4
5
...