Chitin/PLGA blend microspheres as a biodegradable drug delivery system: a new delivery system for protein.

@article{Mi2003ChitinPLGABM,
  title={Chitin/PLGA blend microspheres as a biodegradable drug delivery system: a new delivery system for protein.},
  author={Fwu-Long Mi and Shin-Shing Shyu and Yi-Mei Joy Lin and Yu-Bey Wu and Chih-Kang Peng and Y N Tsai},
  journal={Biomaterials},
  year={2003},
  volume={24 27},
  pages={5023-36}
}
Novel chitin/PLGAs and chitin/PLA based microspheres were developed for the delivery of protein. These biodegradable microspheres were prepared by polymers blending and wet phase-inversion methods. The parameters such as selected non-solvents, temperature of water and ratio of polylactide to polyglycolide were adjusted to improve thermodynamic compatibility of individual polymer (chitin and PLGAs or chitin/PLA), which affects the hydration and degradation properties of the blend microspheres… CONTINUE READING