Chiroptical study and absolute configuration of securinine oxidation products

@article{Chirkin2015ChiropticalSA,
  title={Chiroptical study and absolute configuration of securinine oxidation products},
  author={Egor Chirkin and William Atkatlian and Quyen-Quyen T. Do and Thomas Gaslonde and Thi-hanh Dufat and Sylvie Michel and Pascale Lemoine and Gr{\'e}gory Genta‐Jouve and François-Hugues Por{\'e}e},
  journal={Natural Product Research},
  year={2015},
  volume={29},
  pages={1235 - 1242}
}
Time-dependant density functional theory–electronic circular dichroism spectra prediction was carried out to study the absolute configuration of phyllanthidine-type derivatives 5 and 6, derived from securinine (1) and its enantiomer virosecurinine (2), respectively. This method demonstrated to be very reliable in this alkaloid series. Thus, 5 and 6 shared the same stereochemistry as their parent precursors, confirming the retentive nature of the oxidation sequence. In addition, this study… 
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