Chirality provides a direct fitness advantage and facilitates intermixing in cellular aggregates

  title={Chirality provides a direct fitness advantage and facilitates intermixing in cellular aggregates},
  author={Ashish B. George and Kirill S. Korolev},
  journal={PLoS Computational Biology},
Short Abstract Is it better to be left- or right-handed? The answer depends on whether the goal is making a handshake or winning a boxing match. The need for coordination favors the handedness of the majority, but being different could also provide an advantage. The same rules could apply to microbial colonies and cancer tumors. Like humans, cells often have handedness (chirality) that reflects the lack of mirror symmetry in their shapes or movement patterns. We find that cells gain a… 

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Micropatterned mammalian cells exhibit phenotype-specific left-right asymmetry

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  • Biology
    Microbiology and Molecular Biology Reviews
  • 2006
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