Chirality and Nonsteroidal Anti-Inflammatory Drugs

@article{Hayball1996ChiralityAN,
  title={Chirality and Nonsteroidal Anti-Inflammatory Drugs},
  author={Dr Peter Hayball},
  journal={Drugs},
  year={1996},
  volume={52},
  pages={47-58}
}
The nonsteroidal anti-inflammatory drugs (NSAIDs) are of significant clinical importance and include congeners of many chemical classes, some of which incorporate an asymmetric or chiral carbon atom. With very few exceptions, chiral NSAIDs have been marketed for clinical use as racemates. However, it is apparent that differences, sometimes major, exist between enantiomers in terms of their pharmacological and toxicological properties. With regard to the ability of chiral NSAIDs to inhibit cyclo… CONTINUE READING