Chiral separation of flurbiprofen enantiomers by preparative and simulated moving bed chromatography.

@article{Ribeiro2011ChiralSO,
  title={Chiral separation of flurbiprofen enantiomers by preparative and simulated moving bed chromatography.},
  author={Ant{\'o}nio E Ribeiro and P. Gomes and L. Pais and A. Rodrigues},
  journal={Chirality},
  year={2011},
  volume={23 8},
  pages={
          602-11
        }
}
  • António E Ribeiro, P. Gomes, +1 author A. Rodrigues
  • Published 2011
  • Chemistry, Medicine
  • Chirality
  • This study presents the chiral resolution of flurbiprofen enantiomers by preparative liquid chromatography using the simulated moving bed (SMB) technology. Flurbiprofen enantiomers are widely used as nonsteroidal anti-inflammatory drugs, and although demonstrate different therapeutic actions, they are still marketed as a racemic mixture. The results presented here clearly show the importance of the selection of the proper solvent composition for the preparative separation of flurbiprofen… CONTINUE READING
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