• DOI:10.1002/chir.20978
Corpus ID: 22156472

Chiral separation of flurbiprofen enantiomers by preparative and simulated moving bed chromatography.

@article{Ribeiro2011ChiralSO,
  title={Chiral separation of flurbiprofen enantiomers by preparative and simulated moving bed chromatography.},
  author={Ant{\'o}nio E Ribeiro and P. Gomes and L. Pais and A. Rodrigues},
  journal={Chirality},
  year={2011},
  volume={23 8},
  pages={
          602-11
        }
}

António E Ribeiro, P. Gomes, +1 author A. Rodrigues

Published 2011

Chemistry, Medicine

Chirality

This study presents the chiral resolution of flurbiprofen enantiomers by preparative liquid chromatography using the simulated moving bed (SMB) technology. Flurbiprofen enantiomers are widely used as nonsteroidal anti-inflammatory drugs, and although demonstrate different therapeutic actions, they are still marketed as a racemic mixture. The results presented here clearly show the importance of the selection of the proper solvent composition for the preparative separation of flurbiprofen… CONTINUE READING

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