Chiral separation and modeling of the three-chiral-center beta-blocker drug nadolol by simulated moving bed chromatography.

@article{Wang2004ChiralSA,
  title={Chiral separation and modeling of the three-chiral-center beta-blocker drug nadolol by simulated moving bed chromatography.},
  author={Xin Wang and Chi Bun Ching},
  journal={Journal of chromatography. A},
  year={2004},
  volume={1035 2},
  pages={167-76}
}
Nadolol, a beta-blocker used in the management of hypertension and angina pectoris, has three chiral centers and is currently marketed as an equal mixture of its four stereoisomers. Resolution of three of the four stereoisomers of nadolol was obtained previously by HPLC, with a complete separation of the most active enantiomer (RSR)-nadolol, on a column… CONTINUE READING