Chiral selective effects of doxazosin enantiomers on blood pressure and urinary bladder pressure in anesthetized rats

AbstractAim:To study chiral selective effects of doxazosin enantiomers on blood pressure and urinary bladder pressure in anesthetized rats.Methods:In anesthetized rats, the carotid blood pressure, left ventricular pressure of the heart and the urinary bladder pressure were recorded.Results:Administration of S-doxazosin at 0.25, 2.5, 25, and 250 nmol/kg iv… (More)