Chiral selection in poly(C)-directed synthesis of oligo(G)

@article{Joyce1984ChiralSI,
  title={Chiral selection in poly(C)-directed synthesis of oligo(G)},
  author={G. F. Joyce and G. M. Visser and C. V. Boeckel and J. Boom and L. Orgel and J. Westrenen},
  journal={Nature},
  year={1984},
  volume={310},
  pages={602-604}
}
Theories of the origin of optical asymmetry in living systems place fundamental importance on the amplification of optical asymmetry by an autocatalytic process1–3. The replication of a polynucleotide is one obvious choice for such an autocatalytic growth mechanism. If an optically homogeneous polynucleotide could replicate by directing the polymerization of monomers of the same handedness, while excluding monomers of the opposite handedness, its chiral descendants would come to dominate what… Expand
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TLDR
Guanosine 5′-phosphor)-2-methylimidazolide (2-MeImpG) undergoes an efficient, buffer-independent, template-directed oligomerization in the presence of poly(C) at pH values above 7.6. Expand
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The oligomerization of (guanosine 5'-phosphor)-2-methylimidazolide on a poly(C) template proceeds efficiently at temp. as high as 37 degrees, although the helical complex formed by the template andExpand
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TLDR
If poly(C) is incubated with ImpG and an equimolar quantity of the 5′-phosphorimidazolides of adenosine, uridine or cytidine, in the presence of Zn 2+, ImpG is incorporated at least 200 times more efficiently than “incorrect” nucleotides. Expand
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Abstract Pb 2+ is a very effective catalyst for the template-directed self-condensation of guanosine 5′-phosphorimidazolide on a polycytidylate template. In the presence of 0.01 m -Pb 2+ at 0 °C, upExpand
THE ORIGIN OF OPTICAL ACTIVITY
  • G. Wald
  • Chemistry, Medicine
  • Annals of the New York Academy of Sciences
  • 1957
TLDR
I think that organisms acquired optical activity, not as a gift from the inorganic world, but through processes of selection out of originally racemic mixtures, and the nature of such processes is outlined. Expand